2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-137393
    3α,5α-Tetrahydronorethisterone
    3α,5α-Tetrahydronorethisterone is the major urinary metabolites of Norethisterone (HY-B0554).
    3α,5α-Tetrahydronorethisterone
  • HY-120201
    7-Hydroxy coumarin glucuronide sodium
    7-Hydroxy coumarin glucuronide sodium is a benzopyrone and a metabolite of 7-hydroxy coumarin.
    7-Hydroxy coumarin glucuronide sodium
  • HY-123198
    4-Hydroxybufuralol
    4-Hydroxybufuralol is a metabolite of Bufuralol (HY-105124).
    4-Hydroxybufuralol
  • HY-136436R
    Ternidazole hydrochloride (Standard)
    Ternidazole hydrochloride (Standard) is the analytical standard of Ternidazole hydrochloride (HY-136436). This product is intended for research and analytical applications. Ternidazole hydrochloride is a nitroimidazole Antibiotic with anti-pathogenic microbial activity. Ternidazole hydrochloride kills and inhibits the visible growth of Clostridium perfringens type A in vitro. Ternidazole hydrochloride helps improve the therapeutic efficacy against bacterial vaginosis, candidal vaginitis and mixed vaginitis. Ternidazole hydrochloride effectively alleviates chronic alcoholism. Ternidazole hydrochloride can be used in research related to vaginitis, pathogenic microbial infections and chronic alcoholism.
    Ternidazole hydrochloride (Standard)
  • HY-W781963
    7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
    		Control
    7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one is a metabolite of Flubromazepam.
    7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
  • HY-171185
    CP-611,781
    CP-611,781 is a diol metabolite of ezlopitant alkene (CJ-12,458). In human liver microsomes, the apparent KM value of 5.4 μM for the formation of CP-611,781.
    CP-611,781
  • HY-W002110R
    Isohomovanillic acid (Standard)
    Isohomovanillic acid (Standard) is an analytical standard of Isohomovanillic acid (HY-W002110). This product is intended for research and analytical applications. Isohomovanillic acid (3-Hydroxy-4-methoxyphenylacetic acid) is a product of catecholamine metabolism. Isohomovanillic acid can be isolated from urine. Isohomovanillic acid can be used in the research of Parkinson's disease.
    Isohomovanillic acid (Standard)
  • HY-W721612
    Bromebric acid
    		Inhibitor
    Bromobric acid is a derivative of bromoacrylic acid with cytostatic and antineoplastic activity that can form ionic complexes with glucosamine to achieve controlled-release oral administration
    Bromebric acid
  • HY-135334S
    ACP-5862-d4
    ACP-5862-d4 is deuterium labeled ACP-5862. ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM.
    ACP-5862-d<sub>4</sub>
  • HY-W740628
    Nicorandil pyridine oxide
    		Control
    Nicorandil pyridine oxide is a metabolite of the sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (SUR2B/Kir6.2) activator and nitric oxide donor Nicorandil.
    Nicorandil pyridine oxide
  • HY-Y0785S
    Glyoxal-d2
    Glyoxal-d2 is the deuterium labeled Glyoxal (HY-Y0785). Glyoxal is a cytotoxic α-oxoaldehyde. Glyoxal induces cell damage and promotes protein glycation to form advanced glycation end-products (AGEs). Glyoxal is promising for research of oxidative stress-related diseases (such as atherosclerosis, cataract, Alzheimer's disease), and the formation of calcium oxalate kidney stones.
    Glyoxal-d<sub>2</sub>
  • HY-W003371R
    CGP 44 645 (Standard)
    CGP 44 645 (Standard) is the analytical standard of CGP 44 645. This product is intended for research and analytical applications. CGP 44 645 is the methanol metabolite of Letrozole (HY-14248) and is a molecular indicator for evaluating its metabolic kinetics in microsomes in vitro. Levels of CGP 44 645 in rat liver microsomes may be sex-specific.
    CGP 44 645 (Standard)
  • HY-150334
    Rilmazolam
    Rilmazolam is a metabolite of Rilmazafone (HY-106547) and hypnotic agent. Rilmazolam exerts a significant sleep-inducing effect. Rilmazolam can be used in insomnia-related research.
    Rilmazolam
  • HY-Z9082
    Dihydroxy melphatalan
    		Control
    Dihydroxy melphalan is an inactive degradation product of Melphalan (HY-17575).
    Dihydroxy melphatalan
  • HY-134099
    Vamidothion-sulfone
    Vamidothion-sulfone is the oxidative metabolite of the insecticide and acaricide Vamidothion (HY-116870).
    Vamidothion-sulfone
  • HY-109054AS
    O-Desmethyltramadol-d6 hydrochloride
    O-Desmethyltramadol-d6 hydrochloride is a deuterated labeled O-Desmethyltramadol hydrochloride. O-Desmethyltramadol hydrochloride is the main active metabolite of tramadol (Tramadol) and can cross the blood-brain barrier. O-Desmethyltramadol hydrochloride mainly exerts its analgesic effect by activating the µ-opioid receptor (µ-OR).
    O-Desmethyltramadol-d<sub>6</sub> hydrochloride
  • HY-135740
    Diphenhydramine N-oxide
    Diphenhydramine N-oxide is a metabolite of Diphenhydramine (HY-B0303). Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine can across the ovine blood-brain barrier (BBB) .
    Diphenhydramine N-oxide
  • HY-B0602C
    Desvenlafaxine hydrochloride
    Desvenlafaxine (O-Desmethylvenlafaxine) hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor. Desvenlafaxine (O-Desmethylvenlafaxine) hydrochloride is the major metabolite of the antidepressant venlafaxine. Desvenlafaxine (O-Desmethylvenlafaxine) hydrochloride has the potential for the research of depression and related disorders and diseases (extracted from patent WO2009049354A1).
    Desvenlafaxine hydrochloride
  • HY-W585890
    3-Hydroxybenzo[a]pyrene
    3-Hydroxybenzo[a]pyrene (3-OHBaP) is a preferable biomarker to assess exposure to benzo[a]pyrene (BaP) , a carcinogenic agent.
    3-Hydroxybenzo[a]pyrene
  • HY-W495759
    2,3,4,5-Tetrachlorophenol
    		98.50%
    2,3,4,5-Tetrachlorophenol is a metabolite of γ-Lindane, which is an insecticide.
    2,3,4,5-Tetrachlorophenol
Cat. No. Product Name / Synonyms Application Reactivity